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    We previously showed in vivo that coding-end processing is specific for each coding end, suggesting that specific motifs in a coding-end sequence influence nucleotide deletion and p-region formation. On the other hand, upon introduction of an amino acids mixture imitating the swedish preparation vamin, which includes all essential and non-essential amino acids (except for glutamine and asparagine) in proportion as found in the egg white the urea increment values turned out to be inferior than on administration of a mixture containing from among essential amino acids only arginine and histidine, and from among non-essential ones-glycine and glutamic acid. To investigate further the regulation of e2f by cyclin-dependent kinases, we have extended our studies to include additional cyclins and e2f family members.

    The new measures tend to extend the role of social security programs through providing a greater proportion of the population with more comprehensive protection and setting higher benefit rates to replace income lost because of old age, disability, sickness, work injury, unemployment, or death. The reaction of anaphylaxia with desensibilization on guinea pigs and the method of double diffusion in agar gel were used to study the antigenic composition of the rat skeletal muscles 3, 7 and 30 days after their cross sections were connected with polyurethane glue and silk. The different proportions of these enzymes in homogenates and supernatant fractions (106 000 g) testify to a lack of uniformity in the solubility of cathepsins in the organs tested.

    The totality of findings suggests that as to its sensitivity to the composition of the parenterally introduced nutritional mixture and, possibly, dietary regimen-the urea increment is in no way inferior to the cumbersome, and difficulty realizable under clinical conditions method of nitrogen balance as a criterion for the efficacy of parenteral nutrition and deserves a detailed study as regards its clinical application. These results indicate that v-src, but not c-src527, can bypass the requirement for a functional igf-i receptor in the full transformation of mouse embryo fibroblasts and suggest that qualitative and quantitative differences between the two oncogenes can be used to identify some of the signals relevant to the mechanism(s) of transformation. From this number 24 tumours of circumanal glands (20 adenomas and 4 carcinomas) and 13 tumours of sebaceous glands in extraanal localization were found.

    In a synopsis theoretical and experimental problems of the parenteral nutrition are discussed. The radioisotopic method of 131j-labelled albumin was employed to determine the distribution of acidic proteinase activity in some organs and tissues of chickens. R- cells, the focal adhesion kinase, stat1, and p130cas.

    It is shown that in the postoperative period, besides antigens similar to those of the normal muscles, other antigens which may belong to stage-specific ones appears in the fraction of soluble proteins. Although v-src is a more potent inducer of tyrosine phosphorylation than c-src527, the extent of phosphorylation of either insulin receptor substrate 1 or shc, two of the major substrates of the igf-i receptor, does not seem sufficiently different to explain the qualitative difference in soft agar growth. Depending on the ph of the growth medium, the yeast yarrowia lipolytica secretes both an acidic proteinase and an alkaline proteinase, the synthesis of which is also controlled by carbon, nitrogen, and sulfur availability, as well as by the presence of extracellular proteins.

    The antigenic composition of the skeletal muscles is the same with both methods of connection of the tissues defects. In therapy, surgical extirpation is applied with possible estrogen combination. . In this study, we created a panel of recombination substrates containing actual immunoglobulin and t-cell receptor coding-end sequences and dissected the role of each motif by comparing its processing pattern with those of variants containing minimal nucleotide changes from the original sequence. Our results demonstrate the determinant role of specific sequence motifs on coding-end processing and also the importance of the context in which they are found.


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    To investigate further the regulation of e2f by cyclin-dependent kinases, we have extended our studies to include additional cyclins and e2f family members. Saccharomyces cerevisiae transcription factor gal4 revealed that their transactivation domain was contained within the n-terminal region (amino acids 1 to 79). The new measures tend to extend the role of social security programs through providing a greater proportion of the population with more comprehensive protection and setting higher benefit rates to replace income lost because of old age, disability, sickness, work injury, unemployment, or death. . The antigenic composition of the skeletal muscles is the same with both methods of connection of the tissues defects.

    Depending on the ph of the growth medium, the yeast yarrowia lipolytica secretes both an acidic proteinase and an alkaline proteinase, the synthesis of which is also controlled by carbon, nitrogen, and sulfur availability, as well as by the presence of extracellular proteins. In the neoplastic tissue of circumanal adenomas three differentiation degrees of sebaceous cells were identified. The highest enzymatic activities were found in intestine wall, in pancreas, and in liver. Histologically were investigated 37 cases of neoplastic growths and 2 cases of hyperplasia in canine sebaceous glands. The tested organs, with the exception of pancreas, did not show any enzymatic activity of neutral proteinases.

    An e-box sequence within this 69-bp fragment is necessary for high-level expression, but not for rhythmic expression, indicating that per mediates circadian transcription through other sequences in this fragment. From this number 24 tumours of circumanal glands (20 adenomas and 4 carcinomas) and 13 tumours of sebaceous glands in extraanal localization were found. R- cells, a line of mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor i (igf-i) receptor genes, are refractory to transformation by several viral and cellular oncogenes. Malignant neoplasias consisted of tumorously proliferated, lowly differentiated sebaceous cells. The totality of findings suggests that as to its sensitivity to the composition of the parenterally introduced nutritional mixture and, possibly, dietary regimen-the urea increment is in no way inferior to the cumbersome, and difficulty realizable under clinical conditions method of nitrogen balance as a criterion for the efficacy of parenteral nutrition and deserves a detailed study as regards its clinical application. Considerably lower activities were ascertained in kidneys, brain, lungs, and heart. In this study, we created a panel of recombination substrates containing actual immunoglobulin and t-cell receptor coding-end sequences and dissected the role of each motif by comparing its processing pattern with those of variants containing minimal nucleotide changes from the original sequence. These results indicate that v-src, but not c-src527, can bypass the requirement for a functional igf-i receptor in the full transformation of mouse embryo fibroblasts and suggest that qualitative and quantitative differences between the two oncogenes can be used to identify some of the signals relevant to the mechanism(s) of transformation. Thus, the activities of e2f, a family of transcription factors involved in cell proliferation, are regulated by at least two types of cell growth regulators the retinoblastoma protein family and the cyclin-dependent kinase family. Our results demonstrate the determinant role of specific sequence motifs on coding-end processing and also the importance of the context in which they are found.

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